2026 medication guide • W8MD Weight Loss, Sleep & MedSpa Best Weight-Loss Medications: GLP-1 Injections vs. Phentermine/Topiramate Semaglutide and tirzepatide have changed obesity treatment by producing substantially greater average weight loss than older medications. Yet oral phentermine/topiramate remains one of the most effective, popular and cost-conscious non-GLP-1 choices. W8MD physicians help patients choose based on medical conditions, safety, appetite pattern, diet preferences, previous results, insurance and the cost they can sustain. NYC: 718-946-5500 Philadelphia: 215-676-2334 20+ years of physician experience Pills and GLP-1 options Insurance and prior authorization NYC and Philadelphia offices Which medication produces the most weight loss? Among widely used FDA-approved chronic treatments, tirzepatide (Zepbound) produced the greatest average loss in its pivotal obesity trial—about 15% to 20.9% at 72 weeks across maintenance doses. Semaglutide 2.4 ...
W8MD is a physician supervised, non-surgical medical weight loss program available in many states including New York, Philadelphia, and Connecticut. Most W8MD medical weight loss locations accept health insurance for the weight loss physician weights!