Choosing an oral medicine or incretin treatment Phentermine/Topiramate vs GLP-1 Weight Loss Medications Phentermine/topiramate remains a strong oral option, while newer semaglutide and tirzepatide treatments may produce greater average weight loss. The right choice depends on far more than a ranking table. Contact W8MD Comparison at a glance Feature Phentermine/topiramate ER Semaglutide Tirzepatide Form Daily oral capsule Weekly injection or approved daily tablet Weekly injection Major-trial average Often about 8%–11%, dose and study dependent About 15% with Wegovy 2.4 mg in STEP 1 15%–20.9% across SURMOUNT-1 doses Cost Generic equivalents may be relatively affordable Coverage and product strongly affect cost Coverage and dose strongly affect cost Key cautions Pregnancy, glaucoma, hyperthyroidism, heart rate, mood, cognition, stones, metabolic acidosis GI disease, gallbladder, pancreatitis, dehydration, MTC/MEN 2 Similar incretin cautions plus product-specific contraceptive guidance Wh...
W8MD is a physician supervised, non-surgical medical weight loss program available in many states including New York, Philadelphia, and Connecticut. Most W8MD medical weight loss locations accept health insurance for the weight loss physician weights!